Highlights:
-Polydatin attenuates cardiac dysfunction in the diabetic mice.
-Polydatin up-regulates autophagy level in the diabetic hearts via Sirt3 activation.
-Polydatin improves mitochondrial function in the diabetic hearts by Sirt3 activation.
-Polydatin may serve as a drug for curing the chronic diabetic cardiomyopathy.

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