• Curcumin may be helpful against depression, especially atypical depression. No significant difference in efficacy between high and low dosages were found.
• Two active components in saffron, crocin and safranal, also have antidepressant effects, and at least three studies have found saffron is as effective as generic Prozac.
• One of the mechanisms behind curcumin’s beneficial impact on depression appears to be its ability to tame the flames of inflammation, which is now thought to be a foundational cause of depression.

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