Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated with a loss of mitochondrial network homeostasis, but cellular processes causally linking these changes to organismal senescence remain unclear. Here, they show that AMP-activated protein kinase (AMPK) and dietary restriction (DR) promote longevity in C. elegans […]

Pathogenesis of autoimmune disorders, including multiple sclerosis (MS), has been linked to an alteration of the resident microbial commensal community and of the interplay between the microbiota and the immune system. Dietary components such as fiber, acting on microbiota composition, could, in principle, result in immune modulation and, thus, could be used to obtain beneficial […]

Highlights: -Polydatin attenuates cardiac dysfunction in the diabetic mice. -Polydatin up-regulates autophagy level in the diabetic hearts via Sirt3 activation. -Polydatin improves mitochondrial function in the diabetic hearts by Sirt3 activation. -Polydatin may serve as a drug for curing the chronic diabetic cardiomyopathy. Read more…

Self-help by means of dietary interventions can help in management of various disorders including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions necessitate a widespread appeal for both patients as well as clinicians due to factors including affordability, accessibility, and presence of scientific evidences that demonstrate substantial benefits in reducing disease symptoms such as […]